Key Stage 4 subjects include:

English, English Literature, Mathematics, Single Science, Double Award Science, Information Technology, Irish, Design and Realisation (Resistant Materials), History, Home Economics, Religion, Physical Education, Motor Vehicles and Road Users, Art and Design, Music, Occupational Studies, Work Related Learning, Travel and Tourism, Childcare, Essential Skills.

At Key Stage 4 English, Mathematics, Pastoral Care, Careers, PE, Science and Religion are core subjects. In the delivery of the Entitlement Framework St Columban’s collaborates with Southern Regional College.